BRAFV600E 年龄对乳头甲状腺癌复发风险的影响
Joonseon Park1, Solji An1, Kwangsoon Kim1
1Department of Surgery, College of Medicine, The Catholic University of Korea, Seoul 06591, Republic of Korea.
Cancers
|November 25, 2023
概括
患有BRAF V600E阳性乳头甲状腺癌 (PTC) 的年轻患者有更高的复发风险. 年龄对BRAF V600E阴性PTC患者的复发没有影响,表明需要量身定制的治疗策略.
科学领域:
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
- 内分泌学 在内分泌学.
背景情况:
- BRAF V600E阳性与侵袭性乳头甲状腺癌 (PTC) 有关.
- 年龄是PTC的已知预后因素.
- 年龄,BRAF V600E状态和PTC复发风险之间的相互作用仍未得到充分研究.
研究的目的:
- 调查BRAF V600E阳性和阴性PTC中年龄对复发风险的影响.
- 为了比较年轻和老年PTC患者之间的复发率,按BRAF V600E状态分层.
主要方法:
- 对接受甲状腺手术的PTC患者 (2010-2018) 的回顾性审查.
- 分类为BRAF V600E阳性 (n=1768) 和阴性 (n=428) 组.
- 基于年龄的子组分析:年轻 (<35岁) 和老 (≥55岁).
主要成果:
- 在BRAF V600E阳性PTC中,年轻患者的淋巴/血管入侵,淋巴结阳性和复发率较高 (5.9%对2.1%).
- 年龄,淋巴侵袭和N类是BRAF V600E阳性PTC复发的重要风险因素.
- 年轻的BRAF V600E阳性患者的复发风险增加了2.5倍 (OR,2.528;p=0.001).
- 年龄在BRAF V600E-阴性PTC中没有显著影响复发风险.
结论:
- 年龄是影响BRAF V600E阳性PTC复发风险的关键因素,年轻患者面临更高的风险.
- BRAF V600E状态修改了年龄对PTC复发的影响.
- 这些发现支持基于年龄和BRAF V600E突变状态的PTC个性化治疗策略.
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