双边性作为乳头甲状腺癌复发的危险因素
1Department of Surgery, Ewha Womans University Medical Center, 1071 Anyangcheon-ro, Yangcheon-Gu, Seoul 07985, Republic of Korea.
Cancers
|November 25, 2023
概括
与单侧或单点瘤相比,双侧乳头甲状腺癌 (PTC) 增加了复发风险. 双边性是复发的独立预测因素,建议对这些患者进行谨慎管理.
科学领域:
- 内分泌学 在内分泌学.
- 在瘤学瘤学.
- 手术瘤学手术瘤学
背景情况:
- 乳头甲状腺癌 (PTC) 的多焦点与复发风险有关.
- 在PTC中双边性对复发的具体影响仍然不太清楚.
研究的目的:
- 为了研究瘤双边性和乳头甲状腺癌患者的复发之间的关联.
- 确定双边性是否是PTC复发的独立预测因素.
主要方法:
- 对1258名PTC患者进行了回顾性分析,这些患者在2011年至2018年期间接受了全甲状腺切除术.
- 使用Kaplan-Meier生存分析和多变量Cox比例危险建模来评估复发风险.
主要成果:
- 双边PTC的5年无复发生存率为95.7%,单边多焦点PTC为97.0%,单焦点PTC为97.8% (p=0.004).
- 双边性 (HR 2.550),男性性别 (HR 2.010) 和瘤大小 (HR 1.748) 独立地与复发相关.
- 单边多焦点性并没有显著增加复发风险 (HR 1.211).
结论:
- 在PTC中双边性与侵略性特征有关,例如较大的瘤大小和微观的甲状腺外延伸.
- 瘤双边性是乳头甲状腺癌患者复发的独立预测因素.
- 双边PTC患者可能需要量身定制的治疗和警的后续策略.
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