牙异常及其年龄相关的发生在白血病幸存者中
Anna Jodłowska1, Lidia Postek-Stefańska1
1Department of Pediatric Dentistry, Faculty of Medical Sciences in Zabrze, Medical University of Silesia, 40-055 Katowice, Poland.
Cancers
|November 25, 2023
概括
化疗持续时间和剂量与白血病幸存者的牙异常没有相关性. 癌症治疗开始时的年龄是牙发育问题的主要危险因素.
科学领域:
- 儿科瘤学 儿科瘤学
- 牙科医学 牙科医学
- 药理学 药理学是指药理学的学科.
背景情况:
- 抗癌治疗通常涉及多种药物和多种方案,使得识别牙异常的特定风险因素变得复杂.
- 之前的研究因异质治疗方案而面临局限性,阻碍了建立明确的剂量反应关系.
研究的目的:
- 调查化疗持续时间,剂量和用统一方案治疗白血病幸存者的牙异常发生率之间的相关性.
- 确定影响抗瘤治疗期间出现不良牙科影响的关键风险因素.
主要方法:
- 一组7名白血病幸存者 (ALL IC-BFM 2002协议) 接受了临床和放射性牙科检查.
- 检查了医疗记录,以评估化疗细节,包括药物剂量和治疗计划.
- 记录了牙异常,如生长,减少牙大小,根异常和 taurodontia.
主要成果:
- 在密集化疗或整个化疗的持续时间和牙异常的数量之间没有发现显著的相关性.
- 特定化疗药物的累积剂量 (温克里斯,L-阿斯巴拉金酶,甲甲酸盐,环胺,细胞arabine,6-mercaptopurine) 与牙异常的数量没有关系.
- 抗瘤治疗开始时的年龄成为对牙发育有毒损伤的最重要的风险因素.
结论:
- 标准化疗指标,如持续时间和累积药物剂量,可能不是这种患者群体中牙异常的直接预测因素.
- 癌症治疗开始的早期年龄是导致牙发育毒性的关键因素.
- 需要对更大的队列和标准化的协议进行进一步的研究,以充分阐明化疗引起的牙异常的风险因素.
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