液体活检诊断中经济实惠技术的发展:临床实施的关键
George Alexandrou1, Katerina-Theresa Mantikas1, Rebecca Allsopp2
1Centre For Bio-Inspired Technology, Department of Electrical & Electronic Engineering, Imperial College London, London SW7 2BT, UK.
Cancers
|November 25, 2023
概括
液体活检 (LB) 是一种非侵入性的方法,用于检测外围样本中的癌症标记物. 这项技术对早期癌症检测,个性化治疗和改善患者治疗结果充满希望,有可能使癌症治疗更容易获得和负担得起.
科学领域:
- 在瘤学瘤学.
- 分子诊断学 分子诊断学
- 生物技术是生物技术.
背景情况:
- 尽管精准医学取得了进展,癌症仍然是全球主要的健康挑战.
- 对癌症诊断和治疗的不平等机会阻碍了全球减少癌症死亡率的努力.
- 非侵入性液体活检 (LB) 技术分析外围样本以检测瘤特异性的分子变化.
研究的目的:
- 审查目前用于癌症诊断的液体活检技术.
- 讨论临床实践中LB的演变和未来前景.
- 强调准确性,可访问性和可负担性的重要性,以便广泛采用LB.
主要方法:
- 关于液体活检技术的现有文献的审查,包括循环瘤DNA (ctDNA) 和循环瘤细胞 (CTC).
- 分析LB在癌症查,个性化治疗,治疗监测和早期转移检测方面的潜力.
- 与当前黄金标准诊断方法进行LB方法的比较.
主要成果:
- 使用ctDNA和CTC的LB技术已经取得了重大进展,包括瘤特异性标记物.
- LB使得分子变化的推断能够用于各种临床应用,包括风险查和早期检测.
- 优先考虑准确性,可访问性和可负担性对于LB的临床翻译至关重要.
结论:
- 液体活检代表了一种有前途的非侵入性工具,用于推进癌症治疗.
- 新兴技术的进一步开发和整合可以增强LB的能力.
- 更广泛地采用具有成本效益的LB模型可以改善全球癌症患者的治疗结果.
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