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患有类风湿性关节炎的患者的氧化应激介导疗法:系统性审查和元分析

Katarina Djordjevic¹, Andjela Milojevic Samanovic², Mirjana Veselinovic^3,4

¹Department of Pharmacy, Faculty of Medical Sciences, University of Kragujevac, Svetozara Markovića 69, 34000 Kragujevac, Serbia.

Antioxidants (Basel, Switzerland)

|November 25, 2023

概括

抗氧化剂在治疗类风湿性关节炎 (RA) 中表现出适度的影响,减少氧化应激和疾病进展. 这一元分析证实了它们对 RA 患者的潜在益处.

科学领域:

类风湿病学类风湿病学
氧化压力研究研究氧化压力研究
药理学药理学是指药理学的学科.

背景情况:

类风湿性关节炎 (RA) 是一种自身免疫性疾病,其特征是全身和局部氧化应激.
氧化应激在RA病变和疾病进展中起着重要作用.
在RA患者中,心血管风险较高,可能与炎症和氧化应激有关.

研究的目的:

系统地审查和分析有关类风湿性关节炎抗氧化疗法的现有文献.
评估抗氧化剂在减少RA疾病进展和相关心血管风险方面的有效性.
提供RA管理中抗氧化剂临床有效性的最新数据.

主要方法:

根据PRISMA指南进行的系统审查和元分析.
搜索了英语和中文数据库,截至2023年3月,包括PubMed,Embase,Web of Science等.
评估偏差风险和提取临床疗效 (例如,DAS28,HAQ) 和氧化应激标志物的数据.

主要成果:

对30项涉及1652名RA患者的RCT进行的元分析显示,抗氧化剂治疗的作用小到中等 (平均效果大小为0.525).
抗氧化剂治疗显示出具有统计学意义的效果,置信区间为0.276到0.983.
观察到的中度效应表明,在治疗类风湿性关节炎方面,有潜在的临床益处.

结论:

抗氧化剂有效地降低了类风湿性关节炎中的全身和局部氧化应激.
有证据表明,抗氧化剂可以减轻自身免疫性疾病 (如RA) 中的疾病损伤.
进一步的研究可能会巩固抗氧化剂在全面的RA治疗策略中的作用.

关键词:

抗氧化剂抗氧化剂是一种抗氧化剂.临床效率的临床效率炎症标志物炎症标志物这是一个元分析.氧化应激标志物氧化应激标志物类风湿性关节炎类风湿性关节炎

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