精神分裂症和双极性障碍中的差异性细胞相互作用体-歧视性生物标志物作用
Iván Menéndez-Valle1,2,3, Cristina Cachán-Vega1,2,4, José Antonio Boga1,2,5
1Instituto de Investigación Sanitaria del Principado de Asturias (ISPA), Av. del Hospital Universitario, s/n, 33011 Oviedo, Asturias, Spain.
Antioxidants (Basel, Switzerland)
|November 25, 2023
概括
氧化应激显著影响精神分裂症 (SCH) 和双相情感障碍 (BD). SCH表现出更大的细胞损伤,包括内质网膜应激和亡,与严重的氧化失衡有关,与BD中较轻微的影响不同.
科学领域:
- 神经科学是一个神经科学.
- 生物化学 生物化学
- 细胞生物学 细胞生物学
背景情况:
- 精神分裂症 (SCH) 和双相情感障碍 (BD) 是主要的精神疾病,早期症状重叠,使诊断复杂化.
- 氧化应激与SCH和BD有关,但其差异性作用和细胞影响尚不清楚.
研究的目的:
- 研究和比较氧化应激在SCH和BD的系统和细胞水平上的差异性影响.
- 阐明每个疾病特有的分子和细胞互动原子变化.
主要方法:
- 在血和红细胞中分析氧化应激标志物.
- 细胞损伤的评估,包括蛋白质合成,细胞亡,蛋白质体活动,线粒体功能和外周血液单核细胞 (PBMC) 中的自.
主要成果:
- 精神分裂症 (SCH) 显示出明显的红细胞抗氧化剂失衡,扩展到血,并显著影响细胞功能.
- SCH 患者表现出 endoplasmic reticulum (ER) 压力增加,蛋白质体活动和 UPR,以及线粒体功能障碍和缺陷自,导致更高的亡倾向.
- 双极性障碍 (BD) 呈现较轻的氧化损伤,细胞应激和生存途径的激活较少.
结论:
- 由差异性氧化应激驱动的独特的分子和细胞形状将SCH与BD区分开来.
- 这些发现提高了对SCH和BD病理生理学的理解.
- 识别这些差异对于开发有针对性和预防性的治疗策略至关重要.
相关概念视频
Biological Causes of Schizophrenia
60
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
60
Bipolar Disorder
67
Bipolar disorder is a chronic mental health condition marked by significant mood fluctuations, including episodes of mania and depression. Elevated energy levels, heightened mood or irritability, impulsive behavior, reduced sleep needs, rapid speech, racing thoughts, inflated self-esteem, and distractibility characterize mania. Individuals with bipolar disorder often alternate between depressive and manic states, with periods of emotional stability lasting an average of six months to a year.
67
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders
681
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
681


