植物化学物质在癌症中准多个代谢途径
Oleg Shuvalov1, Yulia Kirdeeva1, Alexandra Daks1
1Institute of Cytology of the Russian Academy of Sciences, St. Petersburg 194064, Russia.
Antioxidants (Basel, Switzerland)
|November 25, 2023
概括
植物衍生化合物通过向多个代谢途径,为癌症治疗提供了一个有希望的策略. 这些天然药物在克服耐药性和增强抗癌疗法的有效性方面具有潜力.
科学领域:
- 在瘤学瘤学.
- 癌症中的代谢途径
- 自然产品化学 自然产品化学
背景情况:
- 癌细胞为生长和生存重编程新陈代谢,有助于增殖,入侵和免疫逃避.
- 代谢重新连接是癌症的标志,涉及复杂的,重叠的途径,通常导致治疗阻力,当单独准时.
- 多向药剂对于通过同时抑制几个关键癌细胞过程来提高抗瘤药物的疗效至关重要.
研究的目的:
- 审查表现出针对各种癌症相关代谢途径的多目标活性的植物性天然化合物.
- 探索抑制有氧糖解,呼吸,谷氨酸解,单碳代谢,新生脂质生成和脂肪酸β-氧化的化合物.
- 在临床前和临床环境中提供这些化合物的药理动力学信息.
主要方法:
- 对具有针对多种癌症代谢途径的抑制活性的植物性化合物的文献综述.
- 对针对癌症关键信号通路的化合物的分析.
- 包括来自动物和人类研究的药理动力学数据.
主要成果:
- 确定了几种植物衍生化合物,可以同时抑制各种癌症代谢途径.
- 这些化合物还影响重要的癌症信号通路,表明具有广泛的活性.
- 动物和人类的药物动力学概况被评估为选择的化合物.
结论:
- 针对多个代谢和信号通路的植物性天然化合物具有改善癌症治疗的巨大潜力.
- 这些多向药物可能提供一种策略,以克服各种恶性瘤的治疗阻力.
- 对这些化合物的进一步研究可能会导致新的抗瘤药物开发.
关键词:
癌症的代谢 癌症的代谢葡萄糖氨基溶解是什么葡萄糖溶解是什么脂质新陈代谢 脂质新陈代谢代谢重编程和可塑性多个目标的代理商.自然化合物 自然化合物一个碳代谢的一个碳代谢.脂肪酸的β-氧化过程中的脂肪酸.更多相关视频
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