SARS-CoV-2 影响甲状腺和上腺:一个F-FDG PET/CT 研究
Chiara Lauri1, Giuseppe Campagna1, Andor W J M Glaudemans2
1Nuclear Medicine Unit, Department of Medical-Surgical Sciences and of Translational Medicine, Sant'Andrea University Hospital, "Sapienza" University of Rome, 00161 Rome, Italy.
COVID-19 患者在上腺体中表现出持续的低代谢活性,这表明慢性低功能. 恢复后甲状腺代谢增加,可能表明炎症性甲状腺炎. 临床医生应该监测这些内分泌功能.
科学领域:
- 内分泌学 在内分泌学.
- 核医学就是核医学.
- 传染性疾病 传染性疾病
背景情况:
- SARS-CoV-2感染的是表达ACE-2受体的内分泌腺体.
- 在COVID-19患者中评估甲状腺和上腺的代谢活动至关重要.
研究的目的:
- 在COVID-19患者中评估甲状腺和上腺的代谢活动,使用18F-FDG PET/CT.
- 为了比较COVID-19患者和健康对照者之间的内分泌腺代谢.
主要方法:
- 从三个中心的33名COVID-19患者的18F-FDG PET/CT扫描进行了回顾性分析.
- 甲状腺和上腺的视觉和半定量评估 (SUVmax,SUVmean).
- 与36个年龄相匹配的健康对照进行了比较.
主要成果:
- 诊断时甲状腺吸收没有显著差异,但恢复后吸收增加 (p=0.009).
- 上腺体在诊断时 (p<0.0001) 和康复后 (p=0.0018) 的吸收量显著降低.
- 持续的上腺功能下降,即使在临床康复后也建议.
结论:
- COVID-19可能导致慢性上腺功能下降和潜在的炎症性甲状腺炎.
- 临床医生应在COVID-19感染期间和之后调查和监测垂体-上腺轴和甲状腺功能.
- 18F-FDG PET/CT是评估内分泌腺参与COVID-19的一个有价值的工具.
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