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早期乳腺癌瘤芽的预后价值早期乳腺癌的预后价值

Diogo J Silva^1,2, Gonçalo Miranda¹, Teresina Amaro¹

¹Hospital Pedro Hispano, Local Health Unity of Matosinhos, 4464-513 Matosinhos, Portugal.

|November 25, 2023

概括

瘤芽 (TB) 是早期乳腺癌 (EBC) 的一个重要的预后生物标志物. 高结核病得分与攻击性特征和较短的无病生存期相关,表明需要在治疗决策中使用它.

科学领域:

在瘤学瘤学.
病理学病理学病理学
癌症研究癌症研究

背景情况:

瘤芽 (TB) 与上皮-介质细胞过渡有关,是结直肠癌的预后生物标志物.
瘤芽是瘤微环境的一部分,显示出增加的运动性和侵入性.
高水平的结核病与疾病进展和各种固体瘤的不良结果相关.

研究的目的:

评估瘤芽 (TB) 分析的临床适用性.
建立结核病作为早期乳腺癌 (EBC) 患者的预后因素.

主要方法:

回顾性,单中心的观察性研究.
包括在2014-2015年间诊断的EBC患者.
结核病的分类遵循了2016年国际瘤芽大会的指导方针.

主要成果:

较高的结核病得分与积极的临床病理特征 (例如,血管淋巴细胞入侵,瘤大小,分级,Ki-67) 有显著的相关性.
结核病增加与更高的复发率有关.
高结核病得分与较短的无疾病生存期 (DFS) 有关.

结论:

高结核病与较短的DFS和EBC中的侵略性特征有关.
结核病分析可以确定患有复发高风险的EBC患者.
结核病是EBC中辅助治疗决策的有价值的预后生物标志物.

关键词:

生物标志物生物标志物乳腺癌的早期发展表皮介质介质的过渡.瘤的芽是因为瘤芽.

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