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sFlt-1水平作为预测工具在胎盘功能障碍并发症在多胎妊娠

Valentina Giardini¹, Leonora Grilli¹, Alessandra Terzaghi¹

¹Department of Obstetrics and Gynecology, IRCCS San Gerardo dei Tintori Foundation, University of Milano-Bicocca, 20900 Monza, Italy.

|November 25, 2023

概括

在多胎妊娠中,高水平的可溶性fms类铁酶-1 (sFlt-1) 可能预测不良结果. 在这项研究中,低sFlt-1水平与没有不良事件有关.

科学领域:

产科和妇科产科和妇科
孕产妇和胎儿医学孕产妇和胎儿医学
生殖生物学生殖生物学

背景情况:

高血压障碍 (HDs) 和胎儿生长限制 (FGR) 影响单胎妊娠,但它们在多胎妊娠中的预测知之甚少.
可溶性fms类铁酶-1 (sFlt-1) 是一种具有潜在临床实用性的血管原生标记物.

研究的目的:

调查sFlt-1对住院多胎妊娠中不良产科结果的预测价值.
评估sFlt-1在预测多胎妊娠中与HD和/或FGR相关并发症方面的表现.

主要方法:

在怀孕20周后对39例患有HD/FGR的多胎妊娠进行了回顾性分析.
分类为高 (≥15,802 pg/mL) 和低sFlt-1水平组.
建立了高sFlt-1值,基于不复杂的单独怀孕数据.

主要成果:

在低sFlt-1组中没有报告任何不良结果 (例如,早产<34周,HELLP综合征,ICU入院,紧急剖腹产).
研究队列包括39例多胎妊娠.

结论:

血清sFlt-1截止值≥15,802 pg/mL可以有效预测多胎妊娠中不良的产科结果.
这种预测值在HD/FGR病例中不论妊娠年龄和胆管状况如何,都是正确的.

关键词:

血管新生标志物血管新生标志物内皮质功能障碍在内皮质功能障碍胎儿生长限制限制胎儿生长在怀孕期间的高血压疾病.多重怀孕多重怀孕的情况产科并发症产科并发症孕前症是什么意思 sFlt-1 这是一个很好的方法.

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