甲福明使用与患有2型糖尿病的阿兹海默症患者中发展严重痴呆症的风险之间的关联
Ying Xue1,2,3, Xiangqun Xie2,3
1Department of Pharmacy and Therapeutics, School of Pharmacy, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Biomedicines
|November 25, 2023
概括
在阿尔茨海默病 (AD) 和2型糖尿病 (T2DM) 患者中,使用甲胺并没有显著降低严重痴呆的风险. 这一发现无论APOE ε4基因型状态如何,都是如此.
科学领域:
- 神经科学是一个神经科学.
- 老年学是指老年学的学科.
- 药理学 药理学是指药理学的学科.
背景情况:
- 阿尔茨海默病 (AD) 和2型糖尿病 (T2DM) 是普遍存在的疾病.
- 甲福明是一种常见的T2DM药物,具有潜在的神经保护作用.
- 目前正在调查APOE基因型在甲胺对认知能力下降的影响中的作用.
研究的目的:
- 调查甲福明使用与阿尔茨海默病和T2DM患者严重痴呆风险之间的关联.
- 探索APOE基因型对这种关联的潜在调解.
主要方法:
- 从NACC数据库 (2005-2021) 分析了1306名患有AD和T2DM的参与者.
- 倾向性得分匹配创建了一个由1042名参与者组成的队列用于分析.
- 使用了卡普兰-梅尔分析和考克斯的比例危险模型.
主要成果:
- 甲福明使用者和非使用者之间没有严重的无痴呆症生存时间的显著差异 (日志排名p = 0.56).
- 梅特福林的使用与严重痴呆的风险降低无关 (HR,0.96;95% CI,0.63-1.46;p = 0.85).
- 根据APOE ε4载体身份对子组的分析显示了一致的结果.
结论:
- 梅特福林的使用与AD和T2DM患者严重痴呆的风险降低没有显著的关联.
- 在APOE ε4载体和非载体中观察到这种缺乏关联.
- 研究结果表明,在这个人群中,甲胺对严重痴呆症风险没有显著的基因型介导作用.
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