扩展光谱β-乳酸酶 (ESBL):挑战和机遇
Asmaul Husna1,2, Md Masudur Rahman1,3, A T M Badruzzaman2
1Department of Pathology, Faculty of Veterinary, Animal and Biomedical Sciences, Sylhet Agricultural University, Sylhet 3100, Bangladesh.
Biomedicines
|November 25, 2023
概括
扩展谱β-乳糖酶产生肠杆菌 (ESBL-E) 的抗菌素耐药性是一个主要的健康威胁. 需要采取紧急行动,包括快速诊断和"一个健康"的方法,以应对这种日益严重的危机.
科学领域:
- 微生物学 微生物学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 抗菌素耐药性 (AMR),特别是来自扩展谱β-乳糖酶产生肠杆菌 (ESBL-E) 的抗菌素耐药性,是全球关键的健康问题.
- ESBL-E感染往往导致实证抗生素治疗失败,增加发病率和死亡率.
- 在大肠杆菌和肺炎中普遍存在的CTX-M基因型是主要的ESBL类型,通过移动遗传元素传播.
研究的目的:
- 审查ESBL的背景,风险因素,传播和治疗.
- 专注于目前的情况和ESBL-E在南亚及其他地区的未来威胁.
- 突出快速诊断,替代疗法和"一个健康"方法的必要性.
主要方法:
- 关于ESBL-E的文献综述,专注于南亚.
- 对ESBL患病率,耐药性机制和治疗结果的现有数据的分析.
- 综合有关风险因素,传播动态和治疗挑战的信息.
主要成果:
- 由于治疗失败和抗药性增加,ESBL-E构成重大威胁.
- 碳胺耐药性正在出现,需要碳胺节约策略.
- 在南亚,不合理的抗生素使用加剧了ESBL诱导的AMR问题,据报道,超级细菌对最后的抗生素有耐药性.
结论:
- 快速诊断工具和高效的替代治疗方法对于对抗ESBL-E至关重要.
- 强烈建议采用系统监测的"一个健康"方法.
- 迫切需要采取行动,以应对南亚地区和全球范围内不断升级的抗菌素耐药性危机.
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