移植受体中的前列腺癌 - - 对瘤学结果的叙述性审查
Karolina Hanusz1, Piotr Domański1, Kacper Strojec1
1Department of General, Oncological and Functional Urology, Medical University of Warsaw, Poland Lindleya 4, 02-005 Warsaw, Poland.
Biomedicines
|November 25, 2023
概括
前列腺癌 (PCa) 由于瘤突变负担较低,显示免疫治疗反应不佳. 然而,特定的免疫细胞形状会影响预后,移植患者的结果与一般人群相似.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 移植医学 移植医学
背景情况:
- 前列腺癌 (PCa) 具有低瘤突变负担 (TMB) 的特征,限制了免疫治疗的有效性.
- 细胞毒性T淋巴细胞 (CTL) 和CCR4+调节性T细胞 (Tregs) 的升高与PCa预后和进展较差有关.
- 接受脏移植的接受者 (RTRs) 与前列腺癌的治疗选择和结果与一般人群相似.
研究的目的:
- 审查免疫治疗在前列腺癌中的作用,特别是转移性割耐药PCa (mCRPC).
- 探索PCa.中特定免疫细胞透的预后意义.
- 评估RTR中PCa的瘤结果和治疗方法.
主要方法:
- 关于PCa,免疫疗法,免疫细胞透和RTRs的研究成果的文献综述.
- 对包括TMB,CTL和CCR4+Tregs在内的预后标志物的分析.
- 在RTR人群中比较PCa发病率,病理和存活率与非移植人群.
主要成果:
- 免疫疗法在PCa中有效性有限,但在mCRPC中有益.
- 增加的CTL和CCR4+Treg与不良PCa结果相关.
- PCa治疗和RTR的结果,包括激进的逆流体前列腺切除术 (RRP),支臂治疗和机器人辅助的激进前列腺切除术 (RARP),似乎与非移植患者相比.
- 在RTR中,不良病理特征和癌症控制率与一般人群没有显著差异.
结论:
- 虽然PCa通常对免疫疗法反应不佳,但特定的免疫细胞形状会影响预后.
- 具有PCa的RTR体验与一般人群相似的结果,RRP,支架疗法和RARP等标准疗法是有效的.
- 需要进一步的研究来澄清移植和PCa风险/预后之间的关联,并优化治疗策略,特别是在低风险的移植前患者的前列腺切除术方面.
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