时间依赖的流体结构交互模拟简化的人类软 palates
Peng Li1, Marco Laudato1, Mihai Mihaescu1
1Department of Engineering Mechanics, FLOW, KTH Royal Institute of Technology, 10044 Stockholm, Sweden.
Bioengineering (Basel, Switzerland)
|November 25, 2023
概括
这项研究模拟了人类的uvulopalatal系统,以了解阻塞性睡眠呼吸暂停综合征 (OSAS). 增加的空气流会显著变形气道组织,这对于理解OSAS机制至关重要.
科学领域:
- 生物医学工程 生物医学工程
- 流体动力学 流体动力学
- 计算力学 计算力学 计算力学
背景情况:
- 阻塞性睡眠呼吸暂停综合征 (OSAS) 涉及睡眠期间上呼吸道崩.
- 了解在空气流下的软组织动态对于OSAS研究至关重要.
- 这些动态的体内测量通常是不切实际的.
研究的目的:
- 开发一个人体体内流体结构相互作用 (FSI) 的3D模型.
- 模拟与OSAS相关的生理条件.
- 分析呼吸条件对组织振动和流体模式的影响.
主要方法:
- 为uvulopalatal系统开发一个3D计算模型.
- 实施流体结构相互作用 (FSI) 模拟.
- 在不同的呼吸流速下分析振动动力学和流体模式.
主要成果:
- 增加的呼吸流速导致uvulopalatal组织的更大的结构变形.
- 由于频率不匹配,没有观察到流产生的共振.
- 在高流下对称呼吸的显著变形归因于压力反.
结论:
- FSI模型提供了关于在生理空气流下的uvulopalatal组织行为的见解.
- 模拟显示了空气流对OSAS相关的气道动态的影响.
- 该模型有助于理解在OSAS中导致气道崩的机制.
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