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在清醒的小鼠中检测中央听觉处理障碍

Camille Dejean1,2,3, Typhaine Dupont1, Elisabeth Verpy4

  • 1Institut Pasteur, Université Paris Cité, INSERM, Institut de l'Audition, Plasticity of Central Auditory Circuits, F-75012 Paris, France.

Brain sciences
|November 25, 2023
PubMed
概括
此摘要是机器生成的。

研究小鼠的中央听觉处理表明,高频点击列车 (超过60 Hz) 损害神经反应,特别是在皮质下区域. 这一发现对于理解自闭症等神经系统疾病至关重要.

关键词:
审计稳定状态响应的审计反应.自闭症谱系障碍 自闭症谱系障碍醒着的小鼠 醒着的小鼠中央审计处理障碍 中央审计处理障碍

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科学领域:

  • 神经科学是一个神经科学.
  • 听觉神经科学 听觉神经科学
  • 动物模型 动物模型

背景情况:

  • 神经和神经发育障碍 (如自闭症,阿尔茨海默氏症) 通常涉及中央听觉处理缺陷.
  • 听觉稳定状态反应 (ASSR) 的改变与神经元激发抑制失衡有关,这是神经系统疾病中常见的机制.

研究的目的:

  • 开发一种可靠的方法来评估醒着小鼠的皮质下和皮质听觉处理.
  • 在一个Shank3突变小鼠自闭症模型中调查中央听觉处理.

主要方法:

  • 使用长期植入的电极在小鼠上方的下方和听觉皮层.
  • 呈现了不同速率的点击列车,以评估听觉稳定状态响应.
  • 将该协议应用于Shank3突变小鼠,这是自闭症谱系障碍的模型.

主要成果:

  • 开发了一种简单,可靠和持久的方法来访问小鼠复杂的听觉处理.
  • 在Shank3突变小鼠中,在高点击率 (60Hz以上) 时,神经反应受损.
  • 表明这种损伤可以在皮质下检测到,而传统的40 Hz皮质EEG方法无法检测到.

结论:

  • 高频听觉刺激揭示了标准方法无法检测到的中央听觉处理中的缺陷.
  • 这种先进的技术对于在神经疾病的小鼠模型中全面调查听觉处理障碍至关重要.