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喀什果 (Anacardium occidentale) 提取物:可能对下丘脑-垂体-上腺 (HPA) 轴产生影响,调节慢性压力
Guedang Nyayi Simon Désiré1, Foyet Harquin Simplice1, Camdi Woumitna Guillaume1
1Department of Biological Sciences, Faculty of Science, University of Maroua, Maroua P.O. Box 814, Cameroon.
Brain sciences
|November 25, 2023
概括
西方 (AO) 的乙醇提取物在老鼠中显示出显著的抗抑郁作用,改善情绪和认知功能. AO治疗减少了压力标志物和炎症,这表明抑郁症的潜在自然疗法.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 自然产品 化学 化学
背景情况:
- 抑郁症是全球主要的健康问题,需要新的治疗策略.
- 西方 (Anacardium occidentale,简称AO) 是一种具有潜在药用功能的植物.
- 现有的抗抑郁药疗法可能存在局限性,这推动了对替代疗法的研究.
研究的目的:
- 为了研究Anacardium occidentale (AO) 的乙醇提取物在抑郁症的老鼠模型中的抗抑郁作用.
- 评估AO对抑郁相关行为,认知功能和神经化学标记物的影响.
- 为了确定AO提取物中的潜在活性化合物.
主要方法:
- 通过使用不可预测的慢性轻度压力 (UCMS) 诱导了一种老鼠抑郁模型.
- 通过偏爱糖,强迫游泳 (FST) 和新性抑制养试验来评估抗抑郁药类效应.
- 用Y迷宫和莫里斯水迷宫 (MWM) 评估认知功能.
- 神经化学分析包括单胺,氧化应激标志物 (MDA,SOD),细胞因子 (IL-1β,IL-6,TNF-α) 和皮质水平.
- 使用HPLC-MS进行了植物化学分析,以确定活性化合物.
主要成果:
- 在AO提取物显著降低了类似抑郁症的行为,并改善了压力大鼠的认知表现.
- 用AO治疗使单胺水平正常化,减少氧化应激和炎症标志物,降低皮质水平.
- 在HPLC-MS分析中,在AO提取物中鉴定出三烯酸和多,包括乌尔索酸,奥莱阿诺酸,甲素,奎尔素和凯姆菲罗尔.
- AO提取物表现出剂量依赖的抗抑郁药效果,与伊米普拉相当.
结论:
- 西方 (Anacardium occidentale) 的乙醇提取物具有显著的抗抑郁药和焦虑缓解剂等特性.
- 抗抑郁作用的AO可以通过调节皮质系统,单氨基途径,抗氧化和抗炎机制调节.
- 富含三类和多醇的AO提取物代表了抑郁症的有前途的天然治疗剂.
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