再氧化后大脑血流减少与神经综合征连续和血压相关
Yanqiu Liu1,2, Fengjuan Yuan1,2, Zhongwei Peng3
1Institute of Brain Diseases and Cognition, School of Medicine, Xiamen University, Xiamen 361102, China.
Brain sciences
|November 25, 2023
概括
从高海拔 (HA) 返回可以改变大脑血流 (CBF),可能导致神经症状. 这项研究追踪了学生返回低地后的CBF变化和血压.
科学领域:
- 神经学 神经学
- 生理学 生理学 生理学
- 高度医学 高度医学
背景情况:
- 高海拔 (HA) 暴露会改变大脑血流 (CBF) 和大脑循环调节.
- 在返回低地后,HA诱导的CBF变化对神经功能和血压的长期影响尚不清楚.
研究的目的:
- 在HA暴露和随后的再氧化后调查CBF和脑动脉速度的变化.
- 探索CBF,去适应症综合征和从HA返回的个体中的血压之间的关系.
主要方法:
- 使用磁共振成像动脉旋转标记 (ASL) 来测量CBF和跨骨多普勒 (TCD) 来评估脑动脉速度.
- 在基线监测了23名大学生,在从4300米高度返回后一周,以及返回后的三个月.
- 评估了去适应症综合征得分,并测量了CBF和血压参数.
主要成果:
- 在返回低地后的一周,大脑动脉的速度下降,但在三个月后恢复正常.
- 显著的区域CBF下降被观察到在诸如骨和丘脑等区域,随着后中心和额头的增加.
- 全球平均CBF随着时间的推移呈现下降趋势,与静脉压,脉和平均动脉压有负相关.
结论:
- 再氧化后的CBF降低可能会导致从高海拔返回的个体经历的神经症状.
- 从HA恢复后血压升高可能预测随后大脑血流量下降.
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