跨内肝移植系统位放置:对肝硬化患者营养状况的影响
Ilaria de Felice1, Lorenzo Ridola1, Oliviero Riggio1
1Department of Translational and Precision Medicine, Sapienza University of Rome, 00185 Rome, Italy.
Journal of clinical medicine
|November 25, 2023
概括
横性肝内移植系统分流 (TIPS) 放置改善了肝硬化患者的身体组成,增强了肌肉质量和减少脂肪,这与更好的生存率有关.
科学领域:
- 肝病学和胃肠病学 肝病学和胃肠学
- 代谢和营养障碍 代谢和营养障碍
背景情况:
- 营养不良,包括缩症和骨髓硬化症,影响了高达50%的肝硬化患者.
- 改变肌肉数量/质量和脂肪组织变化会对肝病并发症和死亡率产生负面影响.
- 营养状况显著影响慢性肝病的过程和结果.
研究的目的:
- 审查跨内肝移植系统 (TIPS) 对肝硬化患者体质构成的影响.
- 探索TIPS诱导的营养变化背后的病理生理机制.
- 检查TIPS,营养状况和肝脏相关结果之间的关系.
主要方法:
- 审查现有证据在肝硬化患者的TIPS安置.
- 分析TIPS后报告身体组成 (肌肉指数,骨髓炎,脂肪组织) 变化的研究.
- 营养状况改变与临床结果 (如认知功能和生存) 的相关性.
主要成果:
- TIPS安置可以改善骨肌肉指数,并减少骨髓炎.
- 提示与皮下脂肪的增加有关.
- 在sarcopenic患者中,营养改善更为明显,并且与更好的认知功能和生存相关.
结论:
- TIPS安置显著改变了肝硬化患者的身体组成,提供了超出门性高血压管理的潜在好处.
- 在TIPS后肌肉和脂肪分布的改善与改善的临床结果有关.
- 对TIPS对营养状况的机制和临床影响进行进一步研究是有必要的.
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