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代谢综合征和白细胞之间的关联:系统审查和元分析

Elena Raya-Cano¹, Manuel Vaquero-Abellán¹, Rafael Molina-Luque^1,2

¹Nursing, Pharmacology and Physiotherapy Department, University of Cordoba, 14071 Córdoba, Spain.

Journal of clinical medicine

|November 25, 2023

概括

代谢综合征 (MetS) 患者的白细胞数量增加,表明炎症与这种疾病之间存在潜在的联系. 这一发现可能有助于早期诊断和了解MetS病理生理学.

科学领域:

临床医学临床医学
生物化学生物化学
流行病学流行病学

背景情况:

代谢综合征 (MetS) 是一组疾病,包括中心肥胖,高血压,血脂障碍和葡萄糖调节障碍.
MetS显著增加了患2型糖尿病,心血管疾病和全因死亡率的风险.
白血细胞 (WBC) 计数作为炎症和感染的标志物,可能反映代谢状态.

研究的目的:

进行系统性审查和元分析,以评估MetS和WBC计数之间的关联.
为了确定WBC计数作为MetS生物标志物的效果大小.
提供关于白细胞度和代谢综合征之间的关系的强有力的证据.

主要方法:

来自PubMed和Scopus数据库的研究的系统审查和元分析.
使用STROBE工具对方法质量的评估.
使用RevMan对偏差风险的评估和使用Grade Pro的证据质量.

主要成果:

包括14篇文章,其中包括来自21,005名MetS患者和66,339名对照者的数据.
患有MetS的受试者表现出明显更高的白细胞平均计数 (0.64×10⁹/L; 95% CI: 0.550.72; p < 0.00001).
观察到很高的异质性 (I² = 93%).

结论:

在白细胞数量升高和代谢综合征之间存在显著的关联.
对白细胞在MetS病理生理学中的作用的进一步研究可能为早期诊断提供新的途径.
在代谢综合征的背景下,白细胞计数可以作为一个有价值的生物标志物.

关键词:

是一种生物标记物.血清细胞是白细胞.代谢综合征代谢综合征白细胞是白细胞的组成部分.

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