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用于监测性结肠炎疾病活动变化的生物标志物
Yoshihiro Tatsumi1, Kazuki Kakimoto1,2, Azusa Hara1,2
12nd Department of Internal Medicine, Osaka Medical and Pharmaceutical University, Takatsuki City 569-8686, Japan.
富含白的α-2糖蛋白 (LRG) 和IL-6有效监测性结肠炎 (UC) 疾病活动. 便中的calprotectin和IL-6准确地预测临床缓解,而LRG则反映了抗TNF治疗期间的疾病活性.
科学领域:
- 胃肠病学和肝病学
- 临床生物标志物 临床生物标志物
- 炎症性肠道疾病研究研究
背景情况:
- 有限的研究已经评估了性结肠炎 (UC) 疾病活动监测的多种生物标志物.
- 富含血清白蛋白的α-2糖蛋白 (LRG) 是一种新型生物标志物,对抗TNF治疗的反应可能会减弱.
- 需要有效的生物标志物来跟踪UC疾病活动变化.
研究的目的:
- 确定有效的生物标志物来监测UC疾病活动.
- 调查抗TNF抗体治疗对LRG水平的影响.
主要方法:
- 一项前性研究,涉及48名UC患者,血液和便样本被配对.
- 测量了血清LRG,IL-6,albumin前蛋白,hs-CRP,CRP和便calprotectin (FC) 的变化.
- 与疾病活性相关的生物标志物变化 (部分梅奥得分) 和评估的抗TNF治疗效果.
主要成果:
- 血清LRG和IL-6的变化与UC疾病活性变化 (ΔpMayo) 有很强的相关性.
- 与CRP相比,便calprotectin和IL-6在预测临床缓解方面表现出更高的准确性.
- 在抗TNF抗体治疗和LRG水平之间没有观察到任何关联.
结论:
- 胰腺癌疾病活动的变化与LRG,IL-6,前白蛋白,hs-CRP,CRP和FC相关.
- LRG是反映疾病活性的有价值生物标志物,即使在抗TNF抗体治疗期间也是如此.
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