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轻度间歇性寒冷刺激通过肉的神经内分泌途径影响心脏物质代谢

Yuanyuan Liu¹, Lu Xing¹, Yong Zhang¹

¹College of Life Science, Northeast Agricultural University, Harbin 150030, China.

Animals : an open access journal from MDPI

|November 25, 2023

概括

间歇性冷训练通过调节神经内分泌和心脏新陈代谢来增强肉的寒冷耐受性. 这种适应通过特定的基因和蛋白质表达变化改善了应激反应.

科学领域:

动物生理学动物生理学
环境应激反应环境应激反应
代谢途径代谢途径

背景情况:

肉在适应寒冷环境方面面临挑战,这会影响它们的生理和新陈代谢.
了解对寒冷压力的神经内分泌和心脏反应对于改善家禽福利和生产率至关重要.

研究的目的:

研究间歇性寒冷适应对 brojler 神经内分泌和心脏代谢的影响.
为了确定关键的分子途径,涉及冷应激耐受性在肉.

主要方法:

肉接受了不同的冷训练方案 (环境,降低3°C,降低9°C) 和恢复期.
训练后进行了急性冷刺激 (10°C12小时或24小时).
在血液,下丘脑和心脏组织中的基因和蛋白质表达分析 (CACNA1C,PI3K,Akt,mTOR,SREBP1c,FASN,ACC1,SCD,FoxO1,PEPCK,G6Pase,GLUT1,HK1,PFK,LDHB,HSP70,HSP90).

主要成果:

寒冷适应增加了下丘脑中CACNA1C转录和血清诺亚上腺素,同时降低了C9组的胰岛素.
关键的代谢基因 (PI3K,Akt,mTOR,SREBP1c,FASN,ACC1,SCD) 最初是下调的,但在急性感冒刺激后是上调的.
参与葡萄糖代谢和应激反应的基因 (FoxO1,PEPCK,G6Pase,GLUT1,HK1,PFK,LDHB,HSP70,HSP90) 显示出显著的上调,特别是在C3组.

结论:

间歇性冷训练可以提高 brojlers 的冷压力耐受性.
适应涉及神经内分泌信号和心脏物质代谢途径的显著调节.
热冲击蛋白 (HSP70,HSP90) 的升级表明细胞保护机制得到了改善.

关键词:

适应寒冷的适应寒冷的压力是冷的压力.葡萄糖的新陈代谢.脂质新陈代谢脂质新陈代谢神经内分泌神经内分泌

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