支气管喘,呼吸道重塑和肺纤维化作为一个过程的连续步骤
Innokenty A Savin1, Marina A Zenkova1, Aleksandra V Sen'kova1
1Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of the Russian Academy of Sciences, Lavrent'ev Ave 8, 630090 Novosibirsk, Russia.
International journal of molecular sciences
|November 25, 2023
概括
这篇评论探讨了支气管喘,重点关注气道改造和肺纤维化. 它强调需要生物标志物来预测不可逆转的肺部变化,并指导喘治疗.
科学领域:
- 肺部医学 肺部医学
- 免疫学 免疫学 免疫学
- 病理学 病理学 病理学
背景情况:
- 支气管喘是一种复杂的呼吸系统疾病,以炎症,过度反应和空气流阻塞为特征.
- 气道重塑,包括纤维化,是严重和慢性喘的关键特征,往往导致治疗阻力.
- 喘的异质性使诊断变得复杂,特别是将其与慢性阻塞性肺病等疾病区分开来.
研究的目的:
- 审查支气管喘的病因学,病变发生和形态特征.
- 讨论呼吸道改造和肺纤维化作为喘的连续阶段.
- 确定分子标记物和治疗喘预测和治疗的治疗标.
主要方法:
- 关于喘病原,呼吸道改造和肺纤维化方面的文献综述.
- 在喘研究中使用的常见小鼠模型的分析.
- 检查与喘进展和喘后纤维化相关的生物标志物.
主要成果:
- 喘涉及持续的炎症导致结构性呼吸道变化和纤维化.
- 肺纤维化是严重,耐治疗喘的一个重要因素.
- 将喘与其他具有类似结构变化的肺部疾病区分开来是具有挑战性的.
结论:
- 了解喘的分子机制和细胞参与者对于开发新的生物标志物至关重要.
- 确定可靠的生物标志物可以帮助预测不可逆转的肺损伤,并改善喘治疗策略.
- 本综述综合了当前的知识,以指导未来的喘预测和治疗研究.
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