B细胞诱导早期发病的孕产妇炎症,以防止LPS诱导的胎儿排斥
Gina Marie Uehre1,2, Svetlana Tchaikovski2, Atanas Ignatov2
1Experimental Obstetrics and Gynecology, Medical Faculty, Otto-von-Guericke University, 39108 Magdeburg, Germany.
International journal of molecular sciences
|November 25, 2023
概括
母亲B细胞信号传递对于预防早产 (PTB) 至关重要. 失去B细胞功能将免疫平衡转向炎症,导致PTB,而完整的B细胞保护胎儿.
科学领域:
- 免疫学 免疫学 免疫学
- 生殖生物学 生殖生物学
- 孕产妇和胎儿医学 孕产妇和胎儿医学
背景情况:
- 调节性B细胞 (Breg) 和炎症性B细胞之间的平衡对于预防早产 (PTB) 至关重要.
- B细胞信号传递在早期孕产妇和胎儿对炎症攻击的免疫反应中的特定作用尚不清楚.
研究的目的:
- 研究B细胞和B细胞特异性信号通路在早产产生的病变发生过程中的作用.
- 为了阐明B细胞信号如何影响在炎症挑战期间的母胎免疫接口.
主要方法:
- 脂聚糖化物 (LPS) 用于诱导怀孕野生型 (WT),CD19-/-,BMyD88-/-和μMT小鼠在妊娠第16天的炎症.
- 通过测量炎症介导体 (IL-6,TNF-α,IL-17,MCP-1,IL-10,TARC),腹巨中NOS2表达,以及胎盘上浮体,羊水,胎儿血清和妊娠组织中的介导体度来评估免疫反应.
主要成果:
- 与缺乏B细胞的母体相比,WT母体表现出炎症反应,但上调保护因子 (IL-10,TARC),胎儿体内炎症媒介度较低.
- B细胞缺乏 (CD19-/-,BMyD88-/-,μMT) 导致胎儿与母亲界面和胎儿的炎症转移加剧.
- 缺乏B细胞的小鼠经历过早产,而WT小鼠受到保护.
结论:
- 包括CD19和MyD88通路在内的B细胞信号传递对于在怀孕期间维持免疫平衡和预防LPS诱导的早产至关重要.
- 失去B细胞功能会在胎儿与母亲的界面形成炎症环境,导致早产.
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