使用蛋白质-蛋白质相互作用中心治疗癌症疾病的策略
Nicolas Carels1, Domenico Sgariglia2, Marcos Guilherme Vieira Junior3
1Platform of Biological System Modeling, Center of Technological Development in Health (CDTS), Oswaldo Cruz Foundation (FIOCRUZ), Rio de Janeiro 21040-900, RJ, Brazil.
International journal of molecular sciences
|November 25, 2023
概括
这项研究引入了一种针对瘤网络中的蛋白质枢纽的新型癌症治疗策略. 通过重新定位药物和使用RNA干扰 (RNAi) 针对非可药物点,这种方法旨在改善个性化瘤学的患者存活率.
科学领域:
- 在瘤学瘤学.
- 系统生物学 系统生物学
- 网络医学 网络医学
背景情况:
- 新生病,特别是癌症,在瘤的相互作用体内表现出复杂的分子相互作用.
- 无规模网络理论揭示了特定的"枢纽"对于网络完整性至关重要,因此是潜在的治疗目标.
- 了解这些网络漏洞是开发更有效和更合理的癌症治疗的关键.
研究的目的:
- 提出和验证一种系统的策略,用于治疗瘤疾病,以向瘤相互作用体内的蛋白质"枢纽"为中心.
- 探索药物重定位和RNA干扰 (RNAi) 作为可药物和不可药物中心的治疗方式.
- 建立个性化瘤学的框架,通过识别和准关键蛋白节点来改善患者的治疗结果.
主要方法:
- 在瘤相互作用组中识别和选择上调的连接枢纽.
- 药物重定向用于可使用药物的中心,RNA干扰 (RNAi) 用于非可使用药物的目标.
- 通过体外实验,瘤芯片模型,体内研究和临床试验进行验证.
主要成果:
- 证明无规模网络容易受到连接枢纽的有针对性的攻击.
- 证实了恶性细胞攻击性和最大患者存活益处所需的目标数量之间的负相关性.
- 通过向额外的蛋白质来改善治疗结果的潜在潜力,包括那些目前药物治疗通常不解决的蛋白质.
结论:
- 对于瘤疾病治疗,可以制定一个合理的,中心向的策略.
- 药物重新定位和RNA干扰 (RNAi) 为关键蛋白质中心提供了可行的治疗选择.
- 这种方法支持个性化瘤学,通过针对个体瘤网络漏洞量身定制治疗方法,潜在地提高患者的生存率.
关键词:
在RNA-seqqq.它们是RNAiRNAi.吸引力是吸引人的东西.临床试验临床试验临床试验临床试验临床试验药物重用是为了改变药物的用途.集线器是集线器的中心.在体内验证 in vivo验证.互动的作用组.一个芯片上的瘤.这些都是瘤,瘤.更多相关视频
相关概念视频
02:26Protein Networks
4.0K
An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
4.0K
02:04Protein-protein Interfaces
12.5K
Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
12.5K
02:57Targeted Cancer Therapies
7.6K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.6K
02:50Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
01:19Interactions Between Signaling Pathways
6.3K
Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.3K