相关实验视频

Updated: Jul 10, 2025

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

Published on: July 31, 2019

伊弗梅克丁对肠道微生物生态系统的影响

LinShu Liu¹, Karley K Mahalak¹, Jamshed T Bobokalonov¹

¹Dairy and Functional Foods Research Unit, Eastern Regional Research Center, Agricultural Research Service, United States Department of Agriculture, Wyndmoor, PA 19038, USA.

International journal of molecular sciences

|November 25, 2023

概括

伊弗梅克丁 (IVM) 在健康成年人中对肠道微生物产生了轻微的,暂时的影响. 这表明IVM不太可能在健康个体中引起失生症或不良影响.

科学领域:

微生物学微生物学
药理学药理学是指药理学的学科.
胃肠病学胃肠病学

背景情况:

伊弗梅克丁 (IVM) 是人类和兽医的关键抗虫药物.
以前对IVM对肠道微生物群的影响的研究使用了患病的捐赠者,将结果与疾病和其他治疗混.

研究的目的:

研究IVM对健康成年人肠道微生物结构的影响.
通过模拟人类肠道微生物生态系统的受控体外模型来评估IVM的影响.

主要方法:

使用了Triple-SHIME® (人类肠道微生物生态系统模拟器) 模型,使用了健康成年人的便材料.
在标准介质中培养的微生物群落,具有可溶性纤维 (SF) 和不溶性纤维 (ISF).
使用16S rRNA测序,流细胞计和GC-MS.分析微生物组成和代谢物.

主要成果:

伊弗梅克丁 (IVM) 诱导了肠道微生物组成和代谢产生的轻微和短暂的变化.
在肠道微生物群落中没有观察到显著的失调或不良影响.
饮食中的可溶性纤维可能会减轻IVM对肠道微生物群的影响,可能会增加短链脂肪酸的产生.

结论:

伊弗梅克丁 (IVM) 不太可能在健康成年人中引起异常或不良反应.
个体肠道微生物组的组成会影响对IVM的反应.
在IVM治疗期间,食溶解纤维可能会对肠道微生物群产生保护作用.

关键词:

这里是SHIMEIME.我们的肠道微生物组.不溶性纤维纤维是不可溶性的.我从来没有使用过mectin.短链脂肪酸是一种短链脂肪酸.可溶性纤维的可溶性纤维

更多相关视频

Quantitative Polymerase Chain Reaction-based Analyses of Murine Intestinal Microbiota After Oral Antibiotic Treatment

Quantitative Polymerase Chain Reaction-based Analyses of Murine Intestinal Microbiota After Oral Antibiotic Treatment

Published on: November 17, 2018

Quantification of the Potential Impact of Glyphosate-Based Products on Microbiomes

Quantification of the Potential Impact of Glyphosate-Based Products on Microbiomes

Published on: January 10, 2022

相关概念视频

Irritable Bowel Syndrome I: Introduction

Irritable Bowel Syndrome I: Introduction

Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...

Anatomy of the Intestines

Anatomy of the Intestines

Although digestion of proteins, carbohydrates, and lipids may begin in the stomach, it is completed in the intestine. The absorption of nutrients, water, and electrolytes from food and drink also occurs in the intestine. The intestines can be divided into two structurally distinct organs—the small and large intestines.
Small Intestines
The small intestine is an ~7 meter-long tube with an inner diameter of just 2.5 cm. Since most nutrients are absorbed here, the inner lining of the...