非侵入性物理等离子体降低了微生物预刺激的人类牙纤维细胞的炎症反应
Benedikt Eggers1, Matthias Bernhard Stope2, Jana Marciniak3
1Department of Oral, Maxillofacial and Plastic Surgery, University Hospital Bonn, 53111 Bonn, Germany.
International journal of molecular sciences
|November 25, 2023
概括
非侵入性物理等离子体 (NIPP) 可以减少人类牙纤维细胞中有害细菌诱导的炎症. 这表明NIPP可能是牙周病的有前途的新疗法.
科学领域:
- 生物医学工程 生物医学工程
- 口腔生物学 口腔生物学
- 血医学是一种血医学.
背景情况:
- 非侵入性物理等离子体 (NIPP) 具有抗微生物和再生性质,具有越来越多的医疗应用.
- 在牙科领域,特别是牙周炎方面,NIPP的潜力仍然未被充分探索.
- 牙周炎包括由像Fusobacterium nucleatum (F.n. ) 的情况.
研究的目的:
- 研究NIPP对暴露于牙周炎相关细菌的人类牙纤维细胞 (HGFs) 的影响.
- 评估NIPP对有关牙周炎细胞模型中的炎症标志物的影响.
主要方法:
- 来自八名患者的初级HGFs的特征.
- 这些HGF与Fusobacterium nucleatum (F.n. ) 的情况.
- 针对Fn暴露的高基细胞进行了NIPP治疗,随后对IL-6和IL-8水平进行了ELISA分析.
主要成果:
- Fusobacterium nucleatum显著增加了HGFs中的IL-6和IL-8水平.
- 接受NIPP治疗可以抵消Fn引起的IL-6和IL-8上调.
- 这些发现表明,NIPP对牙周细胞有保护作用,防止细菌引起的炎症.
结论:
- 在微生物环境中,NIPP对人类牙纤维细胞具有有益影响.
- NIPP可能为牙周病提供一种新的治疗策略.
- 需要进一步的研究来探索NIPP在牙周病学中的临床应用.
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