在COVID-19后结核病患者的肺炎特征
Galina S Shepelkova1, Vladimir V Evstifeev1, Yuriy S Berezovskiy1,2
1Central Tuberculosis Research Institute, Moscow 107564, Russia.
International journal of molecular sciences
|November 25, 2023
概括
COVID-19 感染可能会重新激活结核病 (TB). 患有COVID-19病史的患者表现出炎症增加和结核病相关微RNA降低调节,表明结核病激活.
科学领域:
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
- 肺部病理学 肺部病理学
背景情况:
- 结核病 (TB) 仍然是全球健康威胁,导致大量死亡.
- SARS-CoV-2 感染对结核病进展的影响尚不清楚.
- 调查COVID-19和结核病之间的相互作用对公共卫生至关重要.
研究的目的:
- 为了比较患有和没有COVID-19病史的患者之间的结核瘤和肺组织的炎症水平.
- 在同时感染的患者中使用结核病相关的微RNA (miRNA) 来描述结核病活动.
- 阐明COVID-19后结核病重新激活的潜在机制.
主要方法:
- 从结核病患者的肺切除材料的组织病理学检查.
- 定量实时PCR (qRT-PCR) 用于测量细胞因子/化学因子基因表达.
- 在血清样本中分析结核病相关的miRNAs.
主要成果:
- 组织学数据表明,在有COVID-19病史的患者中,结核病激活.
- 在COVID-19组中,在结核瘤壁和肺组织外围都观察到高的促炎细胞因子/化学因子水平.
- 在同时感染的患者中,一组特定的结核病相关的miRNAs被下调.
结论:
- 似乎COVID-19感染引发了结核病激活的迹象.
- 增加的炎症和改变的miRNA配置文件表明COVID-19和结核病再激活之间存在联系.
- 需要进一步的研究才能充分理解所涉及的机制.
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