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Updated: Aug 5, 2026

Transposon Mediated Integration of Plasmid DNA into the Subventricular Zone of Neonatal Mice to Generate Novel Models of Glioblastoma
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质母细胞瘤研究中的临床前模型和技术:进化,当前状态和未来途径

Hasan Slika1, Ziya Karimov1,2, Paolo Alimonti3

  • 1Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

International journal of molecular sciences
|November 25, 2023
PubMed
概括

开发更好的临床前模型对于推进质母细胞瘤治疗至关重要. 本综述详细介绍了当前和新兴的模型,以改善这种侵袭性脑癌的研究和患者治疗结果.

关键词:
三维模型是3D模型.动物模型动物模型细胞系细胞系的细胞系.基因工程是基因工程,是基因工程.质母细胞瘤 (glioblastoma) 是一种微流体学 在微流体学方面在临床前的模型中.

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
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