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Updated: Jul 10, 2025

High-Throughput Cellular Profiling of Targeted Protein Degradation Compounds Using HiBiT CRISPR Cell Lines
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基于PROTAC的蛋白质降解作为针对性治疗萨尔科马的有希望的战略

Caterina Mancarella1, Andrea Morrione2, Katia Scotlandi1

  • 1Laboratory of Experimental Oncology, IRCCS Istituto Ortopedico Rizzoli, 40136 Bologna, Italy.

International journal of molecular sciences
|November 25, 2023
PubMed
概括

向蛋白降解 (TPD) 为治疗罕见的儿科肉瘤提供了一种新的方法. 这种创新的疗法,利用蛋白质溶解向嵌合体 (PROTACs),有望克服目前瘤治疗中的向疗法的局限性.

关键词:
在 BET 蛋白质中.这就是BRD9的原因.这就是PROTAC.这就是SMARCA4的标志.降解标签是一种降解标签.融合基因 融合基因 融合基因这种类型的瘤是sarcomas.有针对性的治疗.无处不在的化

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