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Updated: Jul 10, 2025

An Engineered Split-TET2 Enzyme for Chemical-inducible DNA Hydroxymethylation and Epigenetic Remodeling
08:34

An Engineered Split-TET2 Enzyme for Chemical-inducible DNA Hydroxymethylation and Epigenetic Remodeling

Published on: December 18, 2017

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开发针对TET蛋白的新型表观遗传抗癌疗法

Hyejin Kim1, Inkyung Jung1, Chan Hyeong Lee2

  • 1Department of Biological Sciences, Ulsan National Institute of Science and Technology, Ulsan 44919, Republic of Korea.

International journal of molecular sciences
|November 25, 2023
PubMed
概括

该研究确定了线粒作为十一转位 (TET) 蛋白的新型激活剂. 这种化合物增强了TET活性,导致癌细胞死亡,为表观遗传癌症治疗提供了新的途径.

关键词:
通过DNA甲基化.它们是TET蛋白质.癌症治疗疗法 癌症治疗基于细胞的查.表观遗传失调是指表观遗传失调的表观遗传失调.氧甲基化氧甲基化这种药物是Mitoxantrone.

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