YBX1调节卫星IIRNA装载到小细胞外囊中,并促进衰老的表型

Masatomo Chiba1,2, Kenichi Miyata1,3, Hikaru Okawa1

  • 1Division of Cellular Senescence, The Cancer Institute, Japanese Foundation for Cancer Research, Tokyo 135-8550, Japan.

概括

细胞衰老涉及通过小细胞外囊泡 (sEVs) 释放炎症因子 (SASP). 这项研究确定Y盒结合蛋白1 (YBX1) 对于将SATIIRNA加载到sEV中至关重要,促进衰老和炎症,并将YBX1与癌症预后不佳联系起来.

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