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性驱动功能变化在肝纤维化进展和回归的进展和回归
Katia Sayaf1, Ilaria Zanotto2, Daniela Gabbia2
1Department of Surgery, Oncology and Gastroenterology, University of Padova, 35131 Padova, Italy.
International journal of molecular sciences
|November 25, 2023
概括
雄性小鼠对早期肝纤维化表现出更大的敏感性,而雌性小鼠表现出更有效的肝脏再生和修复. 性别影响肝纤维化发展和解决,女性表现出更好的恢复机制.
科学领域:
- 肝病学和免疫学 肝病学和免疫学
- 疾病发病的性别差异 疾病发病的性别差异
背景情况:
- 肝纤维化是一种与慢性肝病相关的可逆性疾病.
- 性影响肝纤维化的发展和进展.
研究的目的:
- 调查肝纤维化和再生的性别机制.
- 为了确定肝损伤反应中女性和男性之间的机制差异.
主要方法:
- 碳四化物给雌性和雄性小鼠服用,剂量增加.
- 八周的洗期来评估肝脏的再生.
- 对免疫细胞群 (Ly6Chigh MoMφs,中性粒细胞) 和活性肝星细胞 (HSCs) 的分析.
主要成果:
- 男性小鼠早期表现出更严重的肝纤维化,与Ly6Chigh单细胞衍生的巨细胞 (MoMφs) 和中性粒细胞有关.
- 在长时间的损伤期间,女性的激活HSC和Ly6Chigh MoMφs增加.
- 洗后,雌性没有显示激活的HSCs,并转向抗纤维性Ly6Clow MoMφs,表明有效的分辨率.
结论:
- 早期肝纤维化主要影响男性,但长期纤维化是性别独立的.
- 与雄性相比,雌性小鼠表现出优越的肝脏修复和再生能力.
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