与衰老相关的上皮质葡萄糖运输的变化
Chien-Te Lee1,2, Hwee-Yeong Ng2, Hua-Rong Zhong1
1Division of Nephrology, Department of Internal Medicine, Kaohsiung Municipal Feng-Shan Hospital (Under Management of Chang Gung Medical Foundation), Kaohsiung 83062, Taiwan.
International journal of molecular sciences
|November 25, 2023
概括
老龄化会增加血糖和脏葡萄糖输送物水平. 硫化捐赠者GYY4137逆转了这些与年龄相关的变化,改善了葡萄糖平衡和脏健康.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 内分泌学 在内分泌学.
- 老年学是一门学科.
背景情况:
- 脏对于葡萄糖平衡至关重要,调节葡萄糖的运输.
- 葡萄糖代谢和功能与年龄相关的变化尚未完全理解.
研究的目的:
- 研究衰老如何影响脏中的葡萄糖运输和新陈代谢.
- 评估硫化供体GYY4137对这些与年龄相关的变化的影响.
主要方法:
- 成年雄性Sprague Dawley大鼠按年龄 (3,6,12个月) 和治疗 (对照或GYY4137) 进行分组.
- 分析了尿路标记物,血糖,HOMA-IR指数,组织学和葡萄糖载体 (SGLT1,SGLT2,GLUT1,GLUT2) 的基因表达以及衰老标记物 (sirtuin,p21).
主要成果:
- 衰老增加了尿蛋白/尿酸,血糖,HOMA-IR和血球硬化.
- GYY4137部分改善了血糖和HOMA-IR,并减少了血球硬化.
- 衰老增加了SGLT1,SGLT2,GLUT1和GLUT2的表达,而GYY4137可以逆转这种情况.
- 老龄化降低了Sirtuin和增加了p21表达.
结论:
- 衰老与葡萄糖平衡受损和脏葡萄糖转运体表达的改变有关.
- GYY4137显示出逆转与年龄相关的脏和代谢功能障碍的潜力.
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