富含白的α-2糖蛋白1 在复杂动脉样硬化中积聚,促进化
Lucile Grzesiak1,2, Ana Amaya-Garrido1,2, Guylène Feuillet1,2
1Institut National de la Santé et de la Recherche Médicale (INSERM), U1297, Institute of Cardiovascular and Metabolic Disease, 31432 Toulouse, France.
International journal of molecular sciences
|November 25, 2023
概括
富含白的α-2糖蛋白1 (LRG1) 有助于动脉样硬化中的血管化. 斑块中LRG1的增加,特别是化区域,表明它在心血管疾病的进展中起作用.
科学领域:
- 心血管生物学 心血管生物学
- 血管细胞生物学 血管细胞生物学
- 动脉样硬化研究 动脉样硬化研究
背景情况:
- 动脉样硬化是心血管疾病的首要原因,斑块并发症如化会影响稳定性和死亡率.
- 虽然已知糖尿病和慢性病等危险因素,但斑块并发症的潜在机制尚不清楚.
- 在糖尿病和慢性脏病患者中观察到循环中的富含白的α-2糖蛋白1 (LRG1) 水平升高.
研究的目的:
- 研究LRG1在动脉样硬化斑块并发症的发展中的作用.
- 为了确定LRG1在动脉样硬化斑块中的起源和功能.
- 阐明LRG1影响血管化的分子机制.
主要方法:
- 使用的阿波利波蛋白E淘汰赛 (ApoE-/-) 小鼠食西方饮食以模拟晚期动脉样硬化.
- 检查了人体动脉内关节切除术样本,以评估LRG1在斑块中的积累.
- 在炎症条件下的内皮细胞和血管光滑肌细胞 (VSMC) 中研究了LRG1的表达.
- 评估了LRG1对VSMC化和SMAD1/5信号通路的影响.
主要成果:
- 发现LRG1会积聚在动脉样硬化斑块中,偏好化区域.
- 炎症媒介在内皮细胞中对LRG1的表达进行了特定的上调,而不是在VSMC中.
- LRG1证明了在VSMC中诱导化的能力.
- 已证明LRG1可以激活VSMC中的SMAD1/5信号通路.
结论:
- 确定LRG1是动脉样硬化中血管化的直接贡献者.
- 这项研究表明,LRG1在斑块并发症的发病过程中起着重要作用.
- LRG1代表了治疗动脉样硬化及其并发症的潜在治疗标.
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