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Updated: Jul 10, 2025

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西斯普拉丁诱导的耳毒性和治疗干预的分子特征

Winston J T Tan1,2, Srdjan M Vlajkovic1,2

  • 1Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Auckland 1023, New Zealand.

International journal of molecular sciences
|November 25, 2023
PubMed
概括

西斯普拉丁化疗会通过损害耳毛细胞引起听力损失. 新的抗氧化和抗炎疗法在预防或减少这种严重的副作用方面表现有前途.

关键词:
西斯普拉丁 (cisplatin) 是一种制剂.甲状腺 (cochlea) 是一种听力损失 听力损失是什么这是一种炎症炎症炎症炎症.耳毒性 耳毒性 耳毒性氧化应激是一种氧化应激.

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5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
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