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Updated: Jul 10, 2025

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

In Silico Identification and Characterization of circRNAs During Host-Pathogen Interactions

Published on: October 21, 2022

病毒编码的循环RNAs:在病毒感染中的作用和意义

Giuseppe Sberna¹, Fabrizio Maggi¹, Alessandra Amendola¹

¹Laboratory of Virology and Biosafety Laboratories, National Institute for Infectious Diseases "L. Spallanzani" IRCCS, 00149 Rome, Italy.

International journal of molecular sciences

|November 25, 2023

概括

循环RNAs (circRNAs),稳定的RNA分子,对于调节细胞过程至关重要,并作为病毒感染和疾病进展的生物标志物. 这篇评论详细介绍了它们在病毒感染期间在细胞通路中的作用.

科学领域:

分子生物学分子生物学
病毒学病毒学
遗传学是一个遗传学.

背景情况:

循环RNAs (circRNAs) 是一种以其稳定性而闻名的共闭合RNA分子.
最初被认为是非功能性的,circRNAs现在被认为是各种细胞过程中的关键调节者.
宿主细胞和病毒都能合成circRNAs,它们在感染,炎症,瘤发生和基因表达中起作用.

研究的目的:

为病毒编码和细胞编码的circRNAs提供最新的概述.
在病毒感染期间阐明circRNAs在细胞通路中的参与.

主要方法:

关于circRNAs当前研究的文献综述.
对研究circRNA生物发生,功能和调节的研究进行分析.
合成关于circRNAs作为病毒感染和疾病中的生物标记物的信息.

主要成果:

循环RNA是无处不在的,稳定的分子,具有多样化的调节功能.
特定的circRNA涉及到关键的细胞过程,包括免疫反应和瘤发生.
循环RNA正在成为诊断病毒感染和监测疾病进展的重要生物标志物.

结论:

循环RNA是细胞调节的组成部分,并在病毒感染中发挥多方面的作用.
了解circRNA机制为新的诊断和治疗策略提供了潜力.
对病毒编码和细胞编码的circRNA进一步的研究对于我们对宿主-病原体相互作用的知识的进步至关重要.

关键词:

感染的生物标志物.环RNA 环RNA 是一个环RNA.圆形的RNARNA是一个圆形的RNA.没有编码的RNA.病毒感染病毒感染

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