在全国代表性的保险索赔数据库中,患者对可操作的药物基因组学药物的暴露
Monica L Bianchini1, Christina L Aquilante1,2, David P Kao2,3
1Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Aurora, CO 80045, USA.
Journal of personalized medicine
|November 25, 2023
概括
患者每年暴露在药物基因组药物中大约77天. 男性性别,年龄较大和慢性疾病与更长时间的药物暴露有关.
科学领域:
- 药物基因组学 药物基因组学
- 药物暴露 药物暴露
- 医疗保健服务研究 医疗服务研究
背景情况:
- 已知药物基因组药物的广泛使用,但对患者暴露时间的数据有限.
- 了解药物暴露对于优化药物基因组测试和治疗策略至关重要.
研究的目的:
- 量化患者暴露于可操作的药物基因组学药物的水平.
- 通过使用保险索赔数据,分析大量全国代表性人口中的药物暴露模式.
主要方法:
- 使用IQVIA PharMetrics® Plus for Academics索赔数据库 (2012-2018) 进行的回顾性队列研究.
- 包括72种临床药物遗传学实施联盟 (CPIC) A级,A/B级或B级药物事件填充的成年人.
- 评估了患者一级的结果,包括覆盖日数 (PDC) 的比例,填充次数和12个月内每次填充的平均日数.
主要成果:
- 对605,355名独特患者进行了超过100万次填充分析.
- 平均PDC为0.21 (77天),表明每年暴露率为21%.
- 药物如 ivacaftor,tamoxifen,clopidogrel,HIV,移植和他类药物显示较高的PDC;大多数是由较少的患者启动的.
结论:
- 男性性别,年龄较大和并发性慢性疾病与药物暴露增加有关.
- 处方填充数据为了解药物基因组药物利用提供了有价值的患者水平指标.
- 结果可以为实施和利用药物基因组测试的策略提供信息.
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