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脑癌的体外模型:从原始到最先进的

Irina Arutyunyan^1,2, Enar Jumaniyazova¹, Andrey Makarov^1,3

¹Research Institute of Molecular and Cellular Medicine, RUDN University, 6 Miklukho-Maklaya Street, 117198 Moscow, Russia.

Journal of personalized medicine

|November 25, 2023

概括

先进的3D细胞模型正在彻底改变头部和部状细胞癌 (HNSCC) 研究. 这些患者衍生模型为临床前研究和个性化癌症治疗策略提供了更好的可访问性,可重复性和相关性.

科学领域:

在瘤学瘤学.
生物技术是生物技术.
细胞生物学细胞生物学

背景情况:

临床瘤学家需要理想的临床前模型来治疗头部和部状细胞癌 (HNSCC).
传统的二维细胞培养在复制本源瘤复杂性方面存在局限性.
蜂技术的进步使得开发更复杂的3D模型成为可能.

研究的目的:

审查体外HNSCC模型的演变和类型.
突出这些模型在临床前研究和个性化医学中的实用性.
在临床研究中讨论HNSCC在体外模型中的潜力.

主要方法:

审查各种体外HNSCC模型系统,包括2D培养,3D球体,有机体和生物打印模型.
讨论每个模型类型的特性和应用.
分析这些模型在理解HNSCC病原和治疗中的作用.

主要成果:

来自患者的3D模型密切模仿本地瘤的组成,架构和突变/病毒载荷.
有各种各样的HNSCC体外模型可供选择,满足不同的研究需求.
这些模型促进了病原体查,微环境研究,生物标志物分析和个性化治疗策略的开发.

结论:

复杂的体外HNSCC模型对于推进癌症研究和治疗至关重要.
这些模型的开发支持将实验发现转化为临床应用.
实验室内HNSCC模型正在为更有效,个性化的癌症治疗铺平道路.

关键词:

三维模型是3D模型.头部和部状细胞癌瘤在体外模型模型中的体外模型.个性化医疗是个性化的医疗.病毒感染病毒感染

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