微环境成分在头部和部状细胞癌中的作用
Enar Jumaniyazova1, Anastasiya Lokhonina1,2,3, Dzhuliia Dzhalilova1,2
1Research Institute of Molecular and Cellular Medicine, Peoples' Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Street, 117198 Moscow, Russia.
Journal of personalized medicine
|November 25, 2023
概括
头部和部状细胞癌 (HNSCC) 是具有攻击性和难以治疗的. 了解瘤微环境 (TME) 和其组成部分,如血管和纤维细胞,是寻找新疗法的关键.
科学领域:
- 在瘤学瘤学.
- 癌症生物学 癌症生物学
- 瘤微环境研究 研究
背景情况:
- 头部和部状细胞癌 (HNSCC) 存在重大临床挑战,包括侵略性进展,频繁复发和治疗结果差.
- 瘤微环境 (TME),包括体和免疫细胞,血管和细胞外基质,在HNSCC的发病过程中起着至关重要的作用.
- HNSCC细胞和TME组件之间的复杂相互作用有助于瘤适应,攻击和治疗耐药性.
研究的目的:
- 阐明特定瘤微环境成分在头部和部状细胞癌症中的复杂作用和相互作用.
- 突出了解TME动态对于改善HNSCC治疗策略的重要性.
- 在HNSCC瘤微环境中识别潜在的生物标志物和治疗点.
主要方法:
- 本综述综合了关于HNSCC瘤微环境的当前研究.
- 专注于新形成的血管,与癌症相关的纤维细胞和细胞外基质的贡献.
- 研究了癌细胞和这些TME元素之间的动态相互作用.
主要成果:
- TME显著影响HNSCC的攻击性和对治疗的抵抗力.
- 新形成的血管,与癌症相关的纤维细胞和细胞外基质是HNSCC进展的关键因素.
- 在TME内部的相互作用促进瘤适应和生存.
结论:
- 更深入地了解TME组件及其相互作用对于推进HNSCC治疗至关重要.
- 准TME元素为新的预后生物标志物和治疗策略提供了潜力.
- 对HNSCC瘤微环境的进一步研究是有必要的,以改善患者的治疗结果.
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