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骨肌肉蛋白质新陈代谢信号的变化是由谷氨酸补充剂和运动诱导的

Carlos Flores Rodrigues Junior¹, Gilson Masahiro Murata², Frederico Gerlinger-Romero³

¹Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo, São Paulo 05508-220, Brazil.

|November 25, 2023

概括

抵抗运动训练 (RET) 和谷氨酸补充剂 (GS) 在成年大鼠中促进肌肉缩. 这两种干预都增加了肌肉纤维大小,GS上调了关键蛋白质合成途径,RET降低了蛋白酶活性.

科学领域:

肌肉生理学肌肉生理学
运动科学运动科学
营养生物化学营养生物化学

背景情况:

骨肌肉质量由蛋白质合成和降解之间的平衡来调节.
众所周知,阻力运动训练 (RET) 能够刺激肌肉缩.
谷氨胺补充剂 (GS) 已被研究其在肌肉蛋白代谢中的潜在作用.

研究的目的:

研究RET和/或GS对参与成年大鼠骨肌肉中蛋白质合成的信号通路的影响.
为了确定组合干预措施是否对肌肉缩产生协同效应.

主要方法:

成年大鼠被分为四组:对照组,仅RET组,仅GS组和RET+GS组.
RET涉及五周的渐进性阻力炼方案 (增加体重的爬梯).
谷氨胺每天通过胃肠道给药.
肌肉质量,纤维横截面积 (CSA),谷氨酸/谷氨酸度,信号蛋白酸化和蛋白质酶体活性在延伸长肌 (EDL) 肌肉中被分析.

主要成果:

与对照组相比,RET和GS都独立增加了EDL肌肉纤维CSA.
GS增加了肌肉中的谷氨胺水平,而RET增加了谷氨酸水平.
RET和GS上调调节了参与肌肉蛋白合成的关键信号蛋白,包括Akt,4E-BP1,p70S6K和S6.
RET导致蛋白质酶活性下降,这表明蛋白质分解减少.

结论:

五周的RET和/或GS有效诱导成年大鼠的肌肉缩,由增加的肌肉纤维CSA证明.
通过激活特定的信号通路 (Akt,4E-BP1,p70S6K,S6) 和通过降低蛋白质酶体活性来减少蛋白质降解的可能性来调节高性效应.

关键词:

26S 蛋白质酶体是一种26S蛋白质体.在 4E-BP-1 中.过度缩的过度缩是一个问题.pS6S6 在线阅读身体炼就是体力炼.蛋白质酶体蛋白质酶体是如何形成的

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