吉诺斯特玛五角 (Gynostemma Pentaphyllum) 增加了运动性能,并改变了健康男性的线粒体呼吸和AMPK
Deepti Nayyar1, Xu Yan1,2, Guoqin Xu3
1Institute for Health and Sport, Victoria University, P.O. Box 14428, Melbourne, VIC 8001, Australia.
Nutrients
|November 25, 2023
概括
补充Gynostemma pentaphyllum通过增强线粒体呼吸和改变关键代谢途径,改善了健康男性的运动表现. 这项研究发现,计时赛的表现和肌肉氧气流量有显著的改善.
科学领域:
- 运动生理学 运动生理学
- 营养生物化学 营养生物化学
- 线粒体生物学 线粒体生物学
背景情况:
- Gynostemma pentaphyllum是一种具有潜在代谢益处的植物.
- AMP激活蛋白激酶 (AMPK) 在细胞能量稳态和线粒体功能中起着至关重要的作用.
- 了解G. pentaphyllum对运动表现和相关分子通路的影响对于运动和代谢健康至关重要.
研究的目的:
- 调查G. pentaphyllum补充剂对健康年轻男性运动表现的影响.
- 为了检查G. pentaphyllum对AMPK激活和线粒体信号通路在人类骨肌肉的影响.
- 评估关键代谢标记物的变化,如瘦素和血糖水平.
主要方法:
- 采用了一项随机,双盲,安慰剂控制的交叉研究设计.
- 十六名健康的未经训练的年轻男性接受了G. pentaphyllum (450毫克/天) 或安慰剂四周,然后是四周的洗期.
- 评估了运动表现 (20公里计时),肌肉AMPK酸化和代谢标志物.
主要成果:
- 补充G. pentaphyllum导致了显著降低勒丁和血糖水平.
- 与安慰剂相比,参与者表现出更好的20公里时间试验性能和更高的肌肉氧气流量.
- 肌肉AMPK Thr172酸化在运动后较早增加,而总ACC-α与G. pentaphyllum较低.
结论:
- 补充G. pentaphyllum似乎可以提高未经训练的男性的运动表现.
- 改善与增强的线粒体呼吸,改变的AMPK和ACC信号,以及减少的血瘦素和葡萄糖有关.
- 需要进一步的研究,以充分阐明机制和长期影响.
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