胰岛素抵抗:日本成年人体内脂肪至瘦的标志物
Masahiro Matsui1, Akira Fukuda2, Saori Onishi1
1Second Department of Internal Medicine, Osaka Medical and Pharmaceutical University, Takatsuki 569-8686, Japan.
Nutrients
|November 25, 2023
概括
脂肪与骨肌肉的比率 (F-FF比率) 与日本成年人胰岛素抵抗 (IR) 有关. 这种身体成分指标,不仅仅是脂肪或瘦肉质量,独立地预测IR,表明代谢平衡的作用.
科学领域:
- 代谢健康 代谢健康
- 身体组成分析 身体成分分析
- 内分泌学 在内分泌学.
背景情况:
- 胰岛素抵抗 (IR) 是代谢障碍的一个关键因素.
- 身体组成,包括脂肪和无脂肪质量,影响代谢健康.
- 了解身体成分指标和IR之间的关系对于公共卫生至关重要.
研究的目的:
- 为了研究胰岛素抵抗 (IR) 与日本成年人的身体组成参数之间的关联.
- 确定特定的身体成分指标,这些指标是IR的独立预测指标.
主要方法:
- 利用生物电阻分析 (BIA) 来评估1186名男性和1441名女性的身体组成.
- 使用恒常状态模型评估IR (HOMA-IR) 评分 (≥2.5) 定义IR.
- 计算的脂肪质量指数 (F指数),无脂肪质量指数 (FF指数) 和它们的比率 (F-FF比率).
主要成果:
- 通过多变量分析,F-FF比被确定为与两性HOMA-IR相关的独立因素.
- 无论是F指数还是单独的FF指数,都不是两个性别HOMA-IR的独立预测指标.
- 在男性和女性之间观察到HOMA-IR,F指数,FF指数和FF-FF比率的显著差异.
结论:
- 脂肪质量与无脂肪质量的比率 (F-FF比率) 是日本成年人胰岛素耐药性的重要指标.
- 保持脂肪和骨肌肉质量之间的平衡可能在控制胰岛素抵抗方面发挥关键作用.
- 身体成分评估,特别是F-FF比率,提供了超出个体质量成分的代谢健康的宝贵见解.
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