在严重病情的成年患者中,基于肠道微生物组的治疗方法 - - 叙述性综述
Shiyue He1,2, Fengyu Lin1,2, Xinyue Hu1,2,3,4
1Center of Respiratory Medicine, Xiangya Hospital, Central South University, Changsha 410008, China.
Nutrients
|November 25, 2023
概括
肠道微生物群调节为重症患者提供治疗潜力. 本综述探讨了基于微生物组的治疗方法,如便微生物群移植 (FMT),用于包括败血症和肺炎在内的疾病.
科学领域:
- 微生物学 微生物学
- 关键护理医学 关键护理医学
- 胃肠病学 胃肠病学
背景情况:
- 肠道微生物群失生症在重症患者中很普遍.
- 恢复肠道微生物群的恒温是一种潜在的治疗策略.
- 基于微生物组的疗法旨在改善严重疾病的结果.
研究的目的:
- 审查基于微生物组的治疗方法在重症成人患者的疗效和局限性.
- 探索应用在诸如呼吸器相关肺炎,败血症,ARDS和COVID-19等疾病中的应用.
- 为了指导选择最佳的肠道微生物群相关的治疗特定的严重疾病的选择.
主要方法:
- 现有文献的叙述性审查.
- 基于微生物组的干预措施的治疗效果和局限性的分析.
- 对各种重症患者群体的证据综合.
主要成果:
- 便微生物群移植 (FMT),选择性消化道去污染 (SDD) 和微生物群衍生疗法显示出有前途.
- 治疗的有效性取决于具体的严重疾病.
- 需要进一步的证据来优化治疗选择.
结论:
- 基于微生物组的治疗方法代表了重症监护的有希望的途径.
- 需要个性化的方法来根据个体患者的病情量身定制治疗.
- 持续的研究对于完善肠道微生物向干预措施至关重要.
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