双极性障碍中维生素D的状态
Zita Späth1, Adelina Tmava-Berisha1, Frederike T Fellendorf1
1Clinical Department of Psychiatry and Psychotherapeutic Medicine, Medical University Graz, 8036 Graz, Austria.
Nutrients
|November 25, 2023
概括
在双相情感障碍患者和对照人群中,维生素D水平没有差异. 然而,较低的24,25(OH) 2D水平和较低的维生素D代谢物比率 (VMR) 与双相情感障碍 (BD) 中躁狂症状增加有关.
科学领域:
- 神经科学和精神病学 在
- 内分泌学和新陈代谢学
背景情况:
- 维生素D在心理健康,特别是双相情感障碍 (BD) 中的作用正在调查中.
- 以前的研究表明,在BD患者中,维生素D状态和情感症状之间存在潜在的联系.
研究的目的:
- 分析双相情感障碍 (BD) 患者的血清度25[OH]D,24,25[OH]2D和维生素D代谢物比率 (VMR).
- 为了将这些维生素D代谢物和VMR与BD中的临床情感症状学和功能相关联.
主要方法:
- 一项涉及170名BD门诊患者和138名健康对照者的横截面研究.
- 使用液体染色学-并联质谱法同时测量25[OH]D和24,25[OH]2D.
- 心理测量评估包括贝克抑郁 inventory-II,汉密尔顿抑郁评分表,年轻狂热评分表,全球功能评估和自杀尝试史.
主要成果:
- 在BD患者和对照人群之间,没有发现25 ((OH) D和24,25 ((OH) 2D度或VMR的显著差异.
- 在年轻狂热评分表和24,25(OH) 2D (r = -0.154,p = 0.040) 之间观察到负相关性.
- 年轻狂热评级表也显示了与VMR的负相关性 (r = -0.238,p = 0.015).
结论:
- 虽然总体维生素D代谢物水平没有差异,但特定的代谢物和它们的比例可能与BD的躁狂症状相关.
- 这些发现表明,较低的24,25(OH) 2D和VMR与躁狂症状严重程度的增加之间存在潜在的关联.
- 建议对更大的样本,经历躁狂发作的人以及纵向评估进行进一步的研究,以确认这些关联.
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