饮食广泛关联,遗传敏感性和结肠直肠癌风险:一项前性队列研究
Dongqing Jin1, Ying Lu2, Wei Wu3
1Department of Colorectal Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310000, China.
Nutrients
|November 25, 2023
概括
高度的酒精和白面包消费增加了结肠直肠癌 (CRC) 的风险. 相反,食用纤维,,,和的摄入量与较低的CRC风险有关.
科学领域:
- 营养科学 营养科学
- 癌症流行病学 癌症流行病学
- 遗传学 遗传学 是一个
背景情况:
- 结肠直肠癌 (CRC) 的发展受到遗传倾向和饮食习惯的影响.
- 了解饮食和遗传易感性之间的相互作用对于CRC预防策略至关重要.
研究的目的:
- 调查139种食物和营养素的摄入量与患结直肠癌 (CRC) 的风险之间的关联.
- 探索饮食因素和遗传易感性之间的潜在相互作用,通过多基因风险评分 (PRS) 评估,与CRC风险相关.
主要方法:
- 一项大规模的队列研究,涉及来自英国生物银行的118,210名参与者.
- 考克斯回归模型用于估计与饮食变量和PRS相关的CRC风险的危险比率 (HRs) 和95%置信区间 (CI).
- 根据使用错误发现率 (FDR) 方法对多次比较进行了统计显著性的调整.
主要成果:
- 在平均12.8年的随访期间,记录了1466起CRC事件.
- 增加的CRC风险与较高的酒精消费 (HR:1.08,95% CI:1.03-1.14) 和白面包 (HR:1.10,95% CI:1.05-1.16) 有关.
- 对饮食纤维,,,,和摄入量观察到与CRC风险的不良关联. 没有发现任何显著的PRS-营养相互作用.
结论:
- 较高的酒精摄入量和白面包是结肠直肠癌的危险因素.
- 充足的食纤维,,,和的摄入量可以提供对CRC的保护作用.
- 关注这些营养素的饮食修改可能是CRC风险降低策略的一个组成部分.
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