益生菌支持口腔微生物群在经过实验性牙炎-一个随机,双盲,安慰剂控制试验后的解决方案期间的弹性
Christine Lundtorp Olsen1,2, Laura Massarenti3, Vincent Frederik Dahl Vendius1
1Section for Clinical Oral Microbiology, Department of Odontology, Faculty of Health and Medical Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.
Nutrients
|November 25, 2023
概括
益生菌有助于恢复实验性牙炎后的口腔健康,在恢复阶段促进有益细菌并减少有害细菌.
科学领域:
- 口腔微生物学 口腔微生物学
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 实验性牙炎是一种常见的口腔疾病.
- 忽视口腔卫生可能导致牙炎并破坏口腔平衡.
- 益生菌可能会影响口腔微生物群和免疫反应.
研究的目的:
- 为了调查益生菌是否可以预防实验性牙炎.
- 为了确定益生菌是否有助于恢复牙炎后的口腔平衡.
- 分析益生菌对口腔微生物群组成和炎症标志物的影响.
主要方法:
- 80名健康参与者接受了14天的口腔卫生疏忽,随后进行了14天的定期卫生.
- 在整个28天的试验中,参与者在28天的试验中服用益生菌或安慰剂.
- 口腔微生物群,斑块评分,探测出血,唾液细胞因子和蛋白酶在基线,第14天和第28天被分析.
主要成果:
- 益生菌的消费与更高的有益细菌的相对丰富性有关,如Rothia和Streptococcus sanguinis.
- 在28日,安慰剂组的潜在有害细菌水平显著提高,包括Lautropia,Prevotella,Fusobacterium和Selenomonas.
- 两组之间在唾液细胞因子,专蛋白或酶活性方面没有发现显著差异.
结论:
- 益生菌支持口腔微生物群在实验性牙炎后的恢复阶段的弹性.
- 益生菌补充剂在维持口腔平衡和促进健康的口腔微生物群方面可能是有益的.
- 需要进一步的研究来探索益生菌影响口腔环境的具体机制.
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