在太空飞行期间和之后预测宇航员的骨适应性
Tannis D Kemp1,2, Bryce A Besler2,3, Leigh Gabel2,3
1Department of Mechanical and Manufacturing Engineering, Schulich School of Engineering, University of Calgary, Calgary, AB T2N 1N4, Canada.
Life (Basel, Switzerland)
|November 25, 2023
概括
这项研究模拟了宇航员在太空飞行和恢复期间使用计算机断层扫描 (CT) 图像的骨健康变化. 虽然静态骨结构的准确预测,动态骨适应率的估计很差.
科学领域:
- 生物医学工程 生物医学工程
- 骨生物学 骨生物学
- 太空医学 太空医学
背景情况:
- 脊椎骨的适应对于骨健康至关重要.
- 以前的方法允许从CT成像中对骨适应进行参与者特定的建模.
- 太空飞行显著影响骨健康,需要精确的监测.
研究的目的:
- 用计算模型估计太空飞行和恢复期间宇航员骨健康状况的变化.
- 评估模型在预测骨结构和适应方面的准确性.
- 应用一个多功能计算框架来测试骨适应模型.
主要方法:
- 宇航员骨 (N=16) 的纵向高分辨率外围定量CT (HR-pQCT) 扫描在发射前获得,并在飞行后的0,6和12个月获得.
- 参与者特定的参数被确定为状骨适应模型.
- 模型预测与观察到的静态和动态骨形态测量以及几何测量 (迪斯系数,对称距离) 进行了比较.
主要成果:
- 模拟和观察到的静态骨形态学显示高相关性 (R2 > 0.94) 与HR-pQCT精度极限附近的误差.
- 反映适应率的动态骨形态测量被模型估计得很差 (p < 0.0001).
- 子系数和对称距离表明观察到的和预测的骨体积之间存在合理的局部匹配.
结论:
- 该计算框架提供了一种多功能方法,用于在特定参与者的基础上测试骨适应模型.
- 该模型准确预测静态骨结构,但与动态适应率作斗争.
- 未来的研究应该将负载或生理因素纳入更复杂的骨适应模型.
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