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Updated: Jul 10, 2025

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
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一个新的MbtI抑制剂复合物的结构研究:面向基于结构的药物发现的优化模型

Matteo Mori1, Stefania Villa1, Laurent R Chiarelli2

  • 1Department of Pharmaceutical Sciences, University of Milan, Via L. Mangiagalli 25, 20133 Milano, Italy.

Pharmaceuticals (Basel, Switzerland)
|November 25, 2023
PubMed
概括

结核病治疗的目标MbtI的新晶体结构揭示了其在开放式和闭合式构造中的活性位点. 这为开发针对Mycobacterium tuberculosis的更有效的抗病毒药物提供了关键的见解.

关键词:
结核病菌菌菌的结核病菌的结核病菌.抗病毒性治疗是一种抗病毒性疗法.同晶体结构的共同晶体结构.铁是铁,铁是铁,铁是铁.盐酸盐合成酶是什么在 siderophore 的位置上.结核病是一种肺结核病.

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Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a...
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