基托桑纳米颗粒用于增强Sida cordifolia提取物的递送:配方,优化和生物活性评估
Perwez Alam1, Mohd Imran2, Shahnawaz Ahmed3
1Department of Pharmacognosy, College of Pharmacy, King Saud University, P.O. Box 2457, Riyadh 11451, Saudi Arabia.
Pharmaceuticals (Basel, Switzerland)
|November 25, 2023
概括
塞达皮叶草 (Sida cordifolia) 水醇提取物载素纳米颗粒 (SCHA-CS-NP) 已优化用于抗糖尿病和抗氧化剂应用. 与对照组相比,优化的纳米颗粒显示出增强的口服输送潜力和优越的生物活性.
科学领域:
- *纳米技术和制药科学 *纳米技术和制药科学
- * * 自然产品化学 自然产品化学
- * 药物输送系统 药物输送系统
背景情况:
- *不断寻找有效的抗糖尿病药物,需要新的药物输送系统.
- * Sida cordifolia水醇 (SCHA) 提取物具有已知的治疗特性.
- * 素纳米颗粒为药物封装和输送提供了一个生物相容的平台.
研究的目的:
- * 通过使用Box-Behnken设计,优化Sida cordifolia水醇提取物载素纳米颗粒 (SCHA-CS-NP).
- * 描述优化纳米粒子的物理化学特性,并评估优化纳米粒子的抗糖尿病和抗氧化能力.
- * 评估SCHA-CS-NP在口服治疗中的疗效.
主要方法:
- *优化SCHA-CS-NP使用Box-Behnken设计,含有奇托和Tween 20,并将速度作为变量.
- *通过粒子大小,多分散性指数,捕获效率,FTIR和DSC进行纳米粒子表征.
- * 药物释放的评估,ex vivo透,抗氧化活性和抗糖尿病潜力.
主要成果:
- *优化的SCHA-CS-NP配方实现了51纳米的粒子大小,84.54%的捕获效率和0.391.1的多分散度指数.
- * 同焦激光扫描显微镜证实与对照组相比,罗达B载SCHA-CS-NP的透率更高.
- *SCHA-CS-NP表现出显著的抗氧化剂 (IC50 = 86.45 μg/mL) 和抗糖尿病剂 (IC50 = 93.71 μg/mL) 活性,分别优于酸和糖.
结论:
- *优化的SCHA-CS-NP配方是一种稳定有效的系统,用于口服Sida cordifolia提取物.
- *SCHA-CS-NP在治疗糖尿病和氧化应激方面显示出有前途的治疗潜力.
- *以纳米粒子为基础的输送增强了天然抗糖尿病剂的生物可用性和有效性.
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