相关实验视频

Updated: Jun 14, 2026

Purification and Reconstitution of TRPV1 for Spectroscopic Analysis
11:53

Purification and Reconstitution of TRPV1 for Spectroscopic Analysis

Published on: July 3, 2018

8.0K

用于治疗用途的TRAF6 N-终端的结构性表征和对新衍生品的计算研究

Omur Guven1, Belgin Sever2,3, Faika Başoğlu-Ünal4

  • 1Department of Molecular Biology and Genetics, Koç University, Istanbul 34450, Turkey.

Pharmaceuticals (Basel, Switzerland)
|November 25, 2023
PubMed
概括

研究人员确定了TRAF6 N端域的结构,揭示了其结合和域组织的关键见解. 这些结构数据使得能够设计出具有有前途治疗潜力的新型TRAF6抑制剂.

关键词:
RING 域名域名是指一个域名.在TRAF6中,土耳其光源 土耳其DeLight在X射线晶体学.癌症 癌症 癌症 癌症 癌症分子建模分子建模药物动力学决定因素结构生物学结构生物学手指的指是什么意思

更多相关视频

Functional Characterization of Endogenously Expressed Human RYR1 Variants07:59

Functional Characterization of Endogenously Expressed Human RYR1 Variants

Published on: June 9, 2021

2.6K
Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation16:02

Demonstration of the Sequence Alignment to Predict Across Species Susceptibility Tool for Rapid Assessment of Protein Conservation

Published on: February 10, 2023

2.7K

相关概念视频

Structure-Activity Relationships and Drug Design01:28

Structure-Activity Relationships and Drug Design

Drug design is a dynamic field that involves discovering and developing new medications based on specific biological targets. This process heavily relies on structure-activity relationships (SAR) and quantitative structure-activity relationships (QSAR) to guide the design and optimization of efficient drugs.
SAR studies the intricate relationship between a drug's chemical structure and biological activity. It focuses on understanding how modifications to a drug's structure can influence its...
Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase01:11

Pharmacogenetics of Drug Targets: β₂-Adrenergic Receptors, Apo E, Thymidylate Synthase

Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...